Approximately 25% of humans have a missense polymorphism in GDF-15 gene resulting in mutation of histidine 202 to aspartate (histidine 6 in the mature domain), close to the N-terminus of the mature growth factor. This variant is associated with phenotypes in prostate cancer, hyperemesis gravidarum (severe morning sickness in pregnancy) and rheumatoid arthritis. Reference: Endocr Rev. 2020 Aug; 41(4): 610–642.
What sets ANSH Labs Total GDF-15 apart from the few available commercial kits is that the Total GDF-15 kit accurately detects Total GDF-15 including the H202D mutations.