Approximately 25% of humans have a missense polymorphism in GDF-15 gene resulting in mutation of histidine 202 to aspartate (histidine 6 in the mature domain), close to the N-terminus of the mature growth factor. This variant is associated with phenotypes in prostate cancer, hyperemesis gravidarum (severe morning sickness in pregnancy) and rheumatoid arthritis. Reference: Endocr Rev. 2020 Aug; 41(4): 610–642.

What sets ANSH Labs Total GDF-15 apart from the few available commercial kits is that the Total GDF-15 kit accurately detects Total GDF-15 including the H202D mutations.

Learn More About Total GDF-15 ELISA

Learn More About GDF-15 (H2O2 Non-Detectable) ELISA

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