Importance of accurate high risk human papillomavirus testing

The human papillomavirus (HPV) is a double-stranded circular DNA virus that can be easily transmitted through sexual contact. HPV infection is one of the most common viral infections of the reproductive tract and is the major risk factor for the development of cervical carcinoma. From over 150 subtypes of HPV being identified, 14 HPV High Risk subtypes are responsible for nearly all cervical cancers, with HPV type 16 and 18 alone accounting for over 70% of cases.

Although over 90% of HPV infections are resolved within 2 years, a small proportion of infections from any of the 14 High Risk HPV subtypes can persist and progress into neoplastic lesions. Despite being specific, cervical cancer screening based on cytology has a high rate of false negatives and often fails to prevent adenocarcinoma of the cervix. Nowadays, cytology and real-time PCR co-testing is considered as the regular screening test for an early and accurate detection of HPV infection in order to prevent cervical cancer.

Fast Track Diagnostics releases CE-labelled multiplex real-time PCR kit for the detection and differentiation of human papillomavirus 16, and human papillomavirus 18 and for the detection of a pool of 12 other High Risk human papillomavirus, including a human endogenous control.

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