Looking for Gold standard colitis model creation reagents? 

This IBD Day, learn how Dextran Sulphate Sodium Salt (DSS)-induced colitis has been used for over 2 decades in preclinical studies and to study Inflammatory Bowel Disease (IBD) pathogenesis. 

MP Biomedical DSS is one of the most widely used  products in the scientific literature because of its high efficacy, high purity (99%) and stability. Over the past 19 years more than 10,000 scientific publications have cited the use of MP Biomedicals’ DSS products and reported successful animal model establishment. 

The advantages of DSS-induced models

The DSS-induced colitis model has some advantages when compared to other animal models of colitis. As mentioned above, an acute, chronic, or relapsing model can easily be generated by changing the concentration and administration cycle of DSS in rats and mice. Moreover, dysplasia that resembles the clinical course of human ulcerative colitis (UC) occurs frequently in the chronic phase of DSS-induced colitis.

Studies validating DSS models using various therapeutic agents for human IBD have shown that DSS-induced colitis can be used as a relevant model for the translation of mice data to human disease.

Dextran Sulphate Sodium salt

  • Induces severe colitis (inflammatory bowel disease)
  • Highest sulfur content – 19%
  • Highest chirality – +104° of specific rotation
  • Lowest pH – 6.2 at 1% solution

Azoxymethane

Azoxymethane (AOM) is a carcinogen that induces O6-methylguanine adducts in DNA leading to G?A transitions.

Effectively induce colitis in your animal models with DSS by using these tips and best practices

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