glucagon regulation research

In an effort to improve treatments for diabetes, ANSH Labs is contributing to glucagon regulation research. Several recent publications have cited the need for accurate, specific, and reliable assays for Glucagon, GLP-1, and Oxyntomodulin. Researchers worldwide have struggled for years trying to find assays that truly measure what they say they measure, and preferably with simple procedures that do not require multiple overnight incubations or complex sample extractions.

The University of Copenhagen, a highly respected institution with hundreds of published articles on metabolism and glucagon regulation, had some disturbing observations in several 2014 studies:

  • None of [the chosen] assays can measure human oxyntomodulin (or glicentin) concentrations with any reliability.
  • Concentrations of endogenous immunoreactive GLP-1 in the samples varied greatly.
  • Five [Glucagon kits] performed so poorly, the results were considered meaningless.
  • The best-performing assay for glucagon [had problems with] its accuracy in the low concentration range.

This is not to say that there are not any viable assays on the market but rather to emphasize the importance of choosing well-validated assays from original manufacturers who have performed extensive linearity, recovery, and cross-reactivity studies. Quality manufacturers will maintain stringent quality control processes to ensure lot-to-lot consistency. Ansh Labs has decades of experience developing some of the most challenging immunoassays. Working with opinion leaders and academic institutions, we have developed and screened hundreds of antibodies to pair and optimize for use in specific and simple Glucagon Regulation assays.

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